efficacy and safety of aripiprazole for treatment of irritability in children with autistic disorder: an open-label study

Efficacy and Safety of Aripiprazole for Treatment of Irritability in Children with Autistic Disorder: An Open-Label Study

Efficacy and Safety of Aripiprazole for Treatment of Irritability in Children with Autistic Disorder: An Open-Label Study

Autistic disorder is characterized by delay and deviance in the development of social interaction and communication as well as specific interests and repetitive restricted behaviors. Symptoms of the disorder are chronic and they are manifested before the age of 3 years. In addition to these symptoms, severe irritability such as aggression, tantrum, mood swings, and self-injury are sometimes see...

Emerging role of aripiprazole for treatment of irritability associated with autistic disorder in children and adolescents

Autistic disorder is a largely misunderstood and difficult to treat neurodevelopmental disorder. Three core domains of functioning are affected by autistic disorder, ie, socialization, communication, and behavior. Signs of autistic disorder may be present early, but are frequently overlooked, resulting in a delay in its diagnosis and a subsequent delay in treatment. No one definitive therapy is...

Aripiprazole in the treatment of irritability in children and adolescents with autistic disorder.

OBJECTIVE The objective of this study was to evaluate short-term efficacy and safety of aripiprazole in the treatment of irritability in children and adolescents with autistic disorder who were manifesting behaviors such as tantrums, aggression, self-injurious behavior, or a combination of these. METHODS This 8-week, double-blind, randomized, placebo-controlled, parallel-group study was condu...

Aripiprazole in children and adolescents with Tourette's disorder: an open-label safety and tolerability study.

OBJECTIVE The aim of this study was to conduct a prospective safety and tolerability study of aripiprazole for the treatment of tics in children and adolescents with Tourette's disorder (TD). METHOD Eleven subjects (10 males) with TD (age 9-19 years, mean 13.36, standard deviation [SD] 3.33) who did not respond or were unable to tolerate previous tic medication were treated with aripiprazole ...

An open-label study of aripiprazole in children with a bipolar disorder.

OBJECTIVE The purpose of this open-label study was to describe the effectiveness of aripiprazole (APZ) in the treatment of children with bipolar disorders suffering from manic symptomatology. METHOD Symptomatic outpatients (Young Mania Rating Scale [YMRS] score ≥15) meeting strict, unmodified, Diagnostic and Statistical Manual of Mental Disorders, 4th edition, diagnostic symptom criteria for ...